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Human Immunodeficiency Virus (HIV)   

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Overview

HIV Infection GraphicHuman Immunodeficiency Virus (HIV) presents a complex knot for scientists to unravel. After initial contact and attachment to a cell of the immune system (e.g. lymphocytes, monocytes), there is a cascade of intracellular events. The endproduct of these events is the production of massive numbers of new viral particles, death of the infected cells, and ultimate devastation of the immune system. However, the knot IS becoming unraveled. These pages attempt to simplify HIV infection at the cellular level. The accompanying diagram shows a number of steps from initial attachment of a viral particle to a lymphocyte through budding of new viruses from that cell.

 

 

 

Follow the sequence of infection in the following steps.

1. ATTACHMENT
Getting in

2. REVERSE TRANSCRIPTION 
From viral RNA to DNA

3. INTEGRATION, TRANSCRIPTION 
a. Viral DNA joins host DNA
b. Making multiple viral RNAs

4. TRANSLATION 
Producing viral proteins

5. VIRAL PROTEASE 
Cleaving viral proteins

6. ASSEMBLY & BUDDING 
Getting out